Deep-dives into psilocybin, LSD, DMT, MDMA, and other psychedelic compounds — their chemistry, effects, history, and science.

In 1976, a chemist named Alexander Shulgin synthesized a molecule that had been sitting in a patent filing since 1912 and decided to try it himself. What he experienced over the next several hours would eventually reshape psychiatric medicine.
Read article →On April 19, 1943, Swiss chemist Albert Hofmann climbed onto his bicycle and began the most consequential commute in pharmacological history. This is the full story of LSD, from ergot fungus to CIA mind control to Johns Hopkins.
Read article →In 1990, Rick Strassman injected DMT into volunteers under a federal research approval at the University of New Mexico. The subjects reported interdimensional beings, alternate realities, and experiences more vivid than waking life, then ate lunch. The complete story of the spirit molecule.
Read article →A Wall Street banker, a healer in Oaxaca, and a mushroom growing guide written under fake names. The complete story of psilocybin, history, brain chemistry, effects, and what the science actually says.
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